Chelsea will host Manchester United in the pick of the fourth round ties of the Capital One Cup.
Holders Liverpool, who host Swansea in a match that will see Reds boss Brendan Rodgers face his former side.
Ties will be played on the week commencing 29 October.
Leeds, who secured a surprise 2-1 win over Everton on Tuesday, face Southampton at Elland Road, while Aston Villa's reward for causing an upset at Premier League champions Manchester City is a trip to Paolo Di Canio's Swindon.
Arsenal, finalists in 2011, head to Reading and Andre Villas-Boas takes his Tottenham side to Norwich in two all-Premier League ties.
"It is a good draw, we're really happy with it," said Royals boss Brian McDermott. "I am sure we'll have a few people at the Madejski Stadium for that.
"We look forward to that but before that we have a big game against Newcastle that we're really looking forward to and tonight's result will be important going into that."
Sunderland's victory over MK Dons has earned them a home fixture against north east rivals Middlesbrough. The two sides met in the fourth round of the FA Cup last year, with Sunderland winning the replay to progress.
Finally, Bradford - the lowest placed side left in the competition - head to Wigan.
Former Swans boss Rodgers expressed his excitement about the draw against his old team.
"The Swansea game will be a special occasion, very much so," said Rodgers.
"It is a wonderful club, a brilliant club, and I was in no rush to leave there. I could only leave there to go to another special club. It will be a great night."
The pairing of Chelsea and Manchester United means the two sides will face each other twice at Stamford Bridge within the space of a few days.
They also meet in the Premier League on Sunday, 28 October, while United host Arsenal at Old Trafford the following Saturday, 3 November.
Capital One Cup fourth round draw:
Sunderland v Middlesbrough
Swindon v Aston Villa
Wigan v Bradford
Leeds v Southampton
Norwich v Tottenham
Liverpool v Swansea
Chelsea v Manchester United
Reading v Arsenal