Carlisle striker Lee Miller is a major fitness concern as the club look to secure a League One play-off place.
Miller, who is the club's top-scorer with 15 goals, picked up a groin injury in the Cumbrians' goalless draw with Scunthorpe on Monday.
With a scan of the injury set to be carried out on Tuesday morning, manager Greg Abbott is fearful.
"It looks like Lee's got a nasty groin injury, which might see the back of him," Abbott told BBC Radio Cumbria.
He added: "He's going to have a scan in the morning and the big man is as honest as they come and he's not happy and I can tell the way they're talking to me and looking at me that there's not going to be great news tomorrow.
"I'm going to prepare myself for that and that will be a massive massive loss for me - that's probably worse than the result (on Saturday)."
Carlisle are currently seventh in League One, level on points with Notts County but with a game in hand as the season nears its conclusion.
But the side struggled the last time Miller was out of first-team action, with the Cumbrians scoring just one goal in three games and picking up three points from a possible nine.