A goal in each half saw mid-table Cambridge United heap more misery on relegated Kettering Town.
Andy Pugh scored his third goal of the season with a strike from 20 yards, while Luke Berry went close.
Goalkeeper Kelvin Jack was shown Kettering's 17th red card of the season when he handled outside the area trying to deny Michael Gash.
Midfielder Ben Ford took over in goal and conceded once, to Harry Pell's close-range strike.
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Cambridge United manager Jez George told BBC Radio Cambridgeshire:
"We dominated the game from start to finish. Kettering have obviously got their problems but we can't feel sorry for them until after the game.
"I felt we went about business in the right way. We played some good football and the only thing that was missing was the finish on the chances we created. It should have been at least three or four by half time.
"So the lack of ability to score a second goal comes to the front of your mind and we just had so many chances to do that it was frightening."
Kettering Town caretaker manager Ashley Westwood told BBC Northampton:
"We've gone behind to a good strike. At half-time, I'd said the game was flat and there to be won. In the second half, we were having a good go and we might have gone on to get something.
"Kelvin Jack has been sent off, and because we haven't got a sub goalkeeper, we've got done. It was an uphill battle we were never going to win.
"Kettering is a decent club, it'll probably be the best stadium in whichever division we're in and it's an attractive job for anyone. I wouldn't want to walk out on this job now."