Tunisia coach Sami Trabesi has no major injury concerns but has hinted that he will make two or three changes.
Striker Saber Khalifa picked up a knee injury against Morocco but should be fit to play on Friday.
Niger centre-back Djibril Souna Moussa is set to return after being suspended for the opening match against Gabon.
But they will have to do without 18 year-old Moutari Amadou, who has flown home after breaking his leg in the first game.
Tunisia are in high spirits after beating arch-rivals Morocco 2-1 in their opener but when they face Niger, one of the competition's weakest teams, coach Sami Trabelsi is leaving nothing to chance.
"Niger is a good team, better than what we saw in their first game [when they lost 2-0 to Gabon]. They will be playing to win because it is their last chance to get to the second round," Trabelsi warned.
"There is good feeling when you win - good stress.
"I hope that we stay here for a very long time. And we leave more emotion for our people."
Meanwhile, Niger technical director Rolland Courbis has sent a clear message to his players.
"I'm trying to calm down their enthusiasm and bring them back down to earth," Courbis explains.
"I have set some objectives that they may not be used to. Before thinking about beating Tunisia in our next match, first think about scoring one goal and taking the first point in Niger's history.
"If we can meet this objective then we could then think about beating Tunisia, which would be a massive achievement."