Regular Equatorial Guinea captain Rodolfo Bodipo is set to miss out again as the forward continues to be affected by injury.
Limping before the first match with an ankle injury, he came on as a late substitute against Libya but was stretchered off with an injury to his left leg.
Attacking midfielder Randy is one booking away from a suspension, as is Senegal's Guirane N'Daw.
Teranga Lions coach Amara Traore has been tipped to drop Mamadou Niang to the bench after the captain was relegated to the B team in a training session.
Equatorial Guinea are on the verge of reaching the Nations Cup quarter-finals despite being tournament outsiders just days ago.
The National Lightning - who are the lowest-ranked team at the finals - earned an opening day 1-0 win against Libya but face a tougher challenge from Senegal.
Stand-in captain Juvenal Edjogo, deputising for Bodipo (who could make his return in the final group game, say team doctors), believes the Libya win can lift the co-hosts to even greater heights.
"It was so important for us to begin the competition with a win and the future is looking bright," said the midfielder.
Senegal, meanwhile, have work to do if they are to get their Nations Cup back on track.
Highly-fancied thanks to a wealth of attacking talent, the Teranga Lions' defence belied its reputation when ripped to pieces by Zambia's Chipolopolo in their surprise 2-1 defeat.
"We must go back to fundamentals like passing, working together and being aggressive," said Traore, whose side were ramshackle at times on Saturday.
Winger Issiar Dia will fancy his chances of starting for the West Africans after impressing as a second-half substitute against Zambia.