Guus Hiddink's Turkey lost 3-0 at home to Croatia in the first leg of their Euro 2012 qualifying play-off.
Ivica Olic tapped in an early opener and Mario Mandzukic headed in before half-time. Vedran Corluka nodded in the third after slack Turkey defending.
Elsewhere, Portugal were held to a 0-0 draw in Bosnia-Hercegovina.
The Czech Republic enjoyed a 2-0 home win over Montenegro, as Arsenal's Tomas Rosicky set up goals for Vaclav Pilar and Tomas Sivok.
Friday's other play-off tie saw the Republic of Ireland take a huge stride towards Euro 2012 with a 4-0 win against Estonia in Tallinn.
In Istanbul, Croatia led as early as the second minute when Olic was left with a simple, close-range finish after goalkeeper Volkan Demirel parried a low cross from Corluka.
Despite a long period of Turkey possession, the visitors doubled their lead in the 32nd minute when Mandzukic headed in a cross from Darijo Srna at the back post.
Turkey's misery was complete in the second half as Corluka headed in after Srna whipped in a free-kick.
The game in Zenica, between Bosnia-Hercegovina and Portugal, produced few goal-scoring chances on a bumpy surface. Portugal had the best of them but Cristiano Ronaldo squandered several openings.
Bosnia-Hercegovina's Manchester City striker Edin Dzeko blazed over the best chance for the home side in the 71st minute. But the hosts, aiming to qualify for their first major international tournament, remain in decent form and are now unbeaten in seven games, conceding once in that time.
In Prague, the Czech Republic dominated possession before eventually breaking through against Montenegro just after the hour mark.
Pilar collected a pass on the edge of the penalty area from Rosicky and rifled in. Rosicky dictated play throughout and his free-kick also supplied Sivok, who headed in his team's second goal in stoppage time.
The Czech team's other hero was goalkeeper Petr Cech, who played with a specially designed mask after breaking his nose playing for Chelsea at Blackburn.