Angola's InterClube leapt to the top of Group A in the Confederation Cup when beating Club Africain 2-1 on Sunday.
The Angolans had been third in the group but replaced the Tunisians when inflicting Africain's first defeat of the group.
Elsewhere, Nigerians Kaduna United climbed off the bottom of the table after beating Asec Mimosas of 2-1.
Goals from Jude Aneke and Siman Yusuf sank the Ivorians, for whom Olanrewaju Kayode replied with a late penalty.
InterClube meanwhile had Manucho Barros to thanks for turning their game around, as they trailed to Hamza Messadi's 68th-minute strike for Africain.
But Barros equalised after 77 minutes before firing home a late winner just two minutes from time.
In Group B, former African champions JS Kabylie of Algeria are out of contention following a 2-0 loss in DR Congo to DC Motema Pembe.
Both goals came late in the game with Inasawa Nfumu scoring a penalty in the 80th minute before Ngandu Junior sealed the result eight minutes later.
The result means Kabylie are bottom of Group B without a single point so far.
In the other game Sunhine Stars and Morocco's MAS drew 1-1 in Nigeria.
The hosts needed a last minute goal from Ajani Ibrahim to take a share of the points after Chemseddine Chtibi had given MAS the lead in the 51st muinute.
The result means that MAS stay one point clear at the top of the table with two games remaining.
Sunshine Stars and Motema Pembe both have exactly the same records with seven points from their four games.