Linfield midfielder Jamie Mulgrew is out of the Carling Premiership game against Dungannon Swifts at Stangmore Park because of a groin injury.
Robert Garrett comes into the squad while Damien Curran replaces the suspended Nathan Hanley.
Donegal Celtic have suffered an injury blow ahead of the visit to Glentoran.
Central defender Darren McNamee fractured a wrist in last week's 5-0 defeat at Linfield and he will be sidelined for six weeks.
Declan O'Hara is set to fill the void for the league encounter at the Oval.
Leaders Linfield and the Glens are the only teams on maximum points after the opening two games.
Ballymena United midfielder Aaron Black is banned for the Showgrounds encounter with Crusaders, who are boosted by the return of Chris Morrow after an ankle injury.
Coleraine go into their home clash with Lisburn Distillery without the suspended Damien McNulty.
A hamstring injury rules Cliftonville defender Kieran Donaghy out of the Solitide showdown against Portadown.
Reds manager Tommy Breslin brings John Convery into the squad as Donaghy's replacement.
Cliftonville is the connection between the two managers in the Mourneview Park game between Glenavon and Carrick Rangers.
Lurgan Blues boss Marty Quinn was in the charge of the title-winning Reds side in 1998 which included Rangers manager Stephen Small.
"Stephen was a hardworking player for me at Cliftonville and I fully expect that to be reflected in how his team plays on Saturday," said Quinn.
"But we are are on a high after coming from three down to draw with Ballymena last weekend."
Ryan Harpur returns to the Glenavon squad after suspension while captain Peter McCann is rated 50/50 to play because of hamstring problem.
Saturday 20 August - 1500 BST kick-off
Ballymena Utd v Crusaders
Cliftonville v Portadown
Coleraine v Lisburn Distillery
Dungannon Swifts v Linfield
Glenavon v Carrick Rangers
Glentoran v Donegal Celtic