A first-half brace from Steve Guinan gave Kidderminster victory at Cambridge.
The striker fired home the first from 12 yards and four minutes later he was left unmarked to head in a Callum Gittings corner.
Cambridge substitute Michael Gash pulled a goal back with his first touch, sweeping in from close range.
Conal Platt fired just wide in the final minute as the home side slipped to a first defeat of the season.
Kidderminster assistant manager Gary Whild told BBC Hereford and Worcester:
"We are pleased after the first set of games with our return.
"We can keep improving. We said that after the first game against Gateshead.
"We were a bit untidy with the ball at Cambridge but we will get better at that."
Cambridge Utd: Naisbitt, Roberts, Coulson, Wylde, McAuley (Kinniburgh 77), Carew, Shaw, Berry, Dunk (Platt 73), Charles, Marriott (Gash 57). Subs Not Used: Brown, Jarvis.
Booked: Charles, Kinniburgh.
Kidderminster: Lewis, Vaughan, Jones, Marshall, Mike Williams, Vincent, Storer, Gittings (Medley 75), Wright (Matt 65), Guinan, Marc Williams (Phelan 70). Subs Not Used: Lyness, Sharpe.
Ref: Declan Ford (Leicestershire)