Defender Scott Gibson scored a brace Annan overturned a two-goal deficit to hammer Queen's Park in Division Three.
Craig Smith fired home from close range after 18 minutes and struck again with a rasping drive nine minutes later.
But David Cox drilled the ball into the top corner after 32 minutes and Graeme Bell fired in just before the break.
Gibson headed in after 59 minutes, Steven Sloan swept in an Ian Harty cross three minutes later and Gibson slotted his second in from 12 yards.
Annan Athletic: Summersgill, Peter Watson, Gibson, Aitken, McGowan, Sloan, Jardine, McKechnie (Holms 81), Cox, Harty, Bell (Jordan Atkinson 85). Subs Not Used: Mitchell, John Watson.
Goals: Cox 32, Bell 45, Gibson 59, Sloan 62, Gibson 65.
Queen's Park: Parry, McGinn, Little, Brough, Meggatt, Gallagher, Smith, Anderson, Watt (Kennedy 77), Daly, Murray (Longworth 63). Subs Not Used: Bradley, Capuano, Strain.
Goals: Smith 18, 27.
Ref: Kevin Clancy