Asec Mimosas of Ivory Coast suffered another blow in the Confederation Cup on Sunday when they lost 1-0 to Angolan side InterClube in Luanda.
In the day's other game, Nigeria's Kaduna United earned a valuable away point with a 0-0 draw against Club Africain of Tunisia.
Asec are bottom of the Group A table with one point from two games so far.
InterClube are top with four points and Club Africain and Kaduna United both have two points after two draws.
In Group B, MAS of Morocco held Motema Pembe of DR Congo 1-1 in Kinshasa to raise hopes of a top-two finish in Group B and a semi-finals place in the second-tier African club competition.
The first of four weekend matches produced a shock as Sunshine Stars of Nigeria came from behind to defeat six-time African title holders JS Kabylie of Algeria 2-1 in Kabylie.
African debutants Sunshine lead the mini-league with a maximum six points from two outings followed by MAS (four) and Motema Pembe (one) while Kabylie are pointless in last position.
Asec, without an African title since defeating Esperance of Tunisia in the 1999 Super Cup match, fell behind after 28 minutes to a Jose Gomes goal in the Angolan city.
Midway through the second half the visitors were reduced to 10 men when Zahui Okou was shown a red card after being cautioned a second time in a bad-tempered match.
MAS prepared for the long journey to Central Africa by defeating Casablanca clubs Raja 2-0 and Wydad 1-0 as they seek to emulate Rabat duo FAR and FUS and bring the Confederation Cup to Morocco a third time since its 2004 launch.
But the visitors soon found themselves pegged back into their half and 1994 African Cup Winners Cup title holders Motema Pembe ended a 661-minute goal drought in all competitions when Tusilu Bazola scored during the opening half.
MAS, who had lost the last two of four away African ties this year, fought back to equalise on 70 minutes through Mehdi el-Bassil and Abdelhadi Halhoul wasted late chances to grab all three points.
Sunshine Stars shocked former title holders JS Kabylie of Algeria when beating them in Group B.
Salim Hanifi put the home side in the lead but Emmanuel Sunday levelled for the debutants before half-time.
Sakibu Atanda snatched the winner 14 minutes before full-time in Africa's second-tier club competition.