Keeper Edwin van der Sar insists Manchester United will have no trouble raising their game for Tuesday's Premier League trip to Newcastle.
United were knocked out of the FA Cup by rivals Manchester City on Saturday.
But Arsenal's 1-1 draw against Liverpool on Sunday means they still have a six-point lead at the top of the table with only six games left.
"It won't be difficult to pick ourselves up. We know how important the league is," said Van der Sar.
"We are in first position, so we just have to make the best of it.
"We were a little bit tired [on Saturday]. The pace of our game was not quick enough.
"We have played a big number of games in the last three or four weeks and against Newcastle we must do better."
After Yaya Toure's 52nd-minute winner ended United's treble hopes on Saturday at Wembley, Dirk Kuyt's dramatic 102nd-minute penalty for Liverpool to rescue a point against the Gunners was the perfect outcome for the Premier League leaders.
They now know 13 points from their last six games will be enough to claim the title for a record 19th time, with games against their two closest rivals, Arsenal (away) and Chelsea (home), still to come.
Sir Alex Ferguson's team have an excellent record at St James' Park and prior to Saturday's defeat they had won seven matches in a row.
"It is always nicer when you find form straight away," added Van der Sar.
"We were a bit scrappy in the first half of the season and conceded some last-minute goals that cost us a few points. When things like that happen, it doesn't do your self-confidence a lot of good.
"On the positive side, you need mental strength in certain games when you keep conceding in the last minute or the ball is not going in.
"It shows the strength of character and the belief this manager has in the quality of his team that we were able to come through those moments."
But the Dutchman insists the overall mood is still good at United as the season enters its crucial final weeks.
"You get confidence when you get on a roll," he commented.
"When you are not struggling and you get your players back it is bound to make everyone feel better about themselves.
"There are goals in the team too and defensively we are sound.
"No one likes to lose at any time but in general there is a good feeling about how things are going."