Esteban Chaves became the first Colombian to win a cycling 'monument' with victory in the Giro di Lombardia.
The Orica-BikeExchange rider, 26, narrowly beat Italian Diego Rosa and Colombian Rigoberto Uran in a sprint over the final 300 metres of the 241km race from Como to Bergamo in Italy.
"I lived in Bergamo for two years, just one kilometre from here, and now I've won it is really special," said Chaves.
Team Sky's Peter Kennaugh, the only Briton to finish, was 26th.
The Giro di Lombardia - featuring 4,400m of climbing - is the last of the season's five 'monuments', after Milan-San Remo, the Tour of Flanders, Paris-Roubaix and Liege-Bastogne-Liege.
Giro di Lombardia result
1. Esteban Chaves (Col/Orica-BikeExchange) 6hrs 26mins 36secs
2. Diego Rosa (Ita/Astana) same time
3. Rigoberto Uran (Col/Cannondale)
4. Romain Bardet (Fra/AG2R) +6secs
5. Davide Villella (Ita/Cannondale) +1min 19secs
6. Alejandro Valverde (Spa/Movistar) +1min 24secs
7. Robert Gesink (Ned/LottoNL) same time
8. Warren Barguil (Fra/Giant)
9. Alessandro De Marchi (Ita/BMC Racing)
10. Pierre Latour (Fra/AG2R)