Trek rider Fabian Cancellara has become the latest big name to withdraw from the Tour de France.
The Swiss pulled out before Wednesday's 11th stage to rest ahead of September's Road World Championships in Spain, his team announced in a statement.
Eight-time stage winner Cancellara, 33, finished second in Sunday's stage nine and was lying 34th overall.
"With more luck, I could have gone home with a result in my pocket," Cancellara said.
"I have done 59 days of competition this season so far and I have another big goal at the end of this season, the world championships.
"It is not a secret that I would like to be in my best shape there, so it is important that I take some rest."
Cancellara is the third Trek rider to pull out, following the withdrawals of 2010 champion Andy Schleck and Danny van Poppel.
After Tuesday's rest day, the Tour resumes on Wednesday with a 187.5km stage from Besancon to Oyonnax.