Glamorgan travel to Friends Life T20 South leaders Hampshire without injured batsman Gareth Rees and bowler James Harris.
Rees has a hand injury while Harris has a foot problem and is set to miss their next two games against Surrey on Friday and Kent on Saturday respectively.
The Welsh county have named an otherwise unchanged squad following their opening day win over Middlesex.
Hampshire's Simon Jones is set to play against his old club Glamorgan.
The ex-England seamer took two wickets in Hampshire's rain-hit victory over Kent on Sunday as the Royals extended their three-match 100% record in this season's tournament.
Glamorgan Dragons: Alviro Petersen (c), Jim Allenby, Chris Ashling, David Brown, Chris Cooke, Mark Cosgrove, Dean Cosker, Robert Croft, Alex Jones, Mike O'Shea, Gareth Rees, Graham Wagg, Mark Wallace (wk), Stewart Walters, Ben Wright.