Former captain Shahid Afridi has withdrawn from Pakistan's squad for two one-day internationals in Ireland because his father is ill.
A Pakistan Cricket Board spokesman said: "Afridi informed us his father has been admitted to hospital for liver treatment and he wants to be with him."
The all-rounder, 31, was last week replaced as one-day skipper by Misbah-ul-Haq, who also leads the Test side.
The two games in Ireland take place at Stormont on Saturday and next Monday.
And Pakistan have decided not to replace Afridi in the squad, instead relying on the other 15 players initially named for the trip.
Afridi, one of the most charismatic and exciting players in world cricket, captained the one-day and Twenty20 teams from early 2010.
The decision to relieve him of the job came as something of a surprise after he led Pakistan to the semi-finals of the World Cup and a 3-2 victory in the West Indies.
He criticised team management after the series in the Caribbean, but the board insisted the decision to replace him was in line with their policy of appointing a captain "on a series to series basis".
Pakistan squad to face Ireland: Misbah-ul-Haq (capt), Younis Khan, Taufiq Umar, Mohammad Hafeez, Asad Shafiq, Azhar Ali, Mohammad Salman (wk), Saeed Ajmal, Abdur Rehman, Umar Akmal, Umar Gul, Wahab Riaz, Tanvir Ahmed, Junaid Khan, Hammad Azam.