Callington will be searching for their third win in the Cornwall Premier 50/50 Cup with victory over Newquay.
Callington are top of the East Division having already beaten St Austell by 150 runs and Grampound by 121 runs.
Werrington, who also have a 100% winning record so far, face fourth placed St Austell.
In the West Division, second placed Paul will be looking to win against Falmouth while leaders St Just are not in action.
The final match of the weekend sees Truro take on Troon.