Scotland's Eilidh Child won her 400m hurdles heat with ease to qualify for the Thursday's final.
And, later on Tuesday, compatriot Mark Dry took bronze in the men's hammer throw at Hampden Park.
A near-full house at the national stadium witnessed Child cruise to the finish line in 55.56 seconds.
"I've been dying to get out there and get the first round out of the way," Child told BBC Sport.
"To have that big crowd out here on a Tuesday morning is amazing. The louder the crowd are the better. It's great to have that boost to get you home."
A lesser than expected number of confirmed entrants to the event mean that the planned semi-final round for the event has been cancelled, so Child has a day to recover before Thursday's final.
The 27-year-old, from Perth, won silver at the 2010 Commonwealth Games in Delhi and is desperate to go one better in Glasgow.
And earlier this month, she won the 400m hurdles at the Diamond League event at Hampden.
"I can't control who does what but I've just got to go and execute that race and hopefully run like I did at the Diamond League and break my PB (personal best)," said Child.
"I want to come away with my fastest time of the year on Thursday night so hopefully it happens."
In one of the final events of the day at Hampden, Dry's mark of 71.64 helped him finish behind Canadian Jim Steacy and England's Nicholas Miller.
Scotland's Guy Learmonth progressed to the semi-final of the men's 800m after finishing fourth in his heat while team-mate Raymond Bobrownicki qualified for the men's high jump final with a mark of 2.20.
Beth Potter missed out on a medal in the final of the women's 10,000m but did record a personal best time of 32:33.4.
There was disappointment for Laura Muir, who finished 11th in the 1,500m having been fourth at one stage. Her pursuit of a medal continues in the 800m heats on Wednesday.