Jeff Evans Commonwealth light-heavyweight title bid against Ovill McKenzie lasted just 15 seconds on Friday night in Halifax.
The 29-year-old from Pontypool agreed to take on McKenzie at late notice, but the Welsh champion was caught with a crushing right hand early on.
Referee Terry O'Connor immediately stopped the fight, with McKenzie regaining the title he held in 2006.
Former cruiserweight WBO champion Enzo Maccarinelli could be a next opponent.
Maccarinelli has decided to step down to light-heavyweight and the Swansea product will make his debut at the 175lb mark on 18 November, against Hungarian Gyorgy Marosi at York Hall in Bethnal Green.
Gary Lockett-trained Evans had hoped to emulate featherweight Lee Selby and become Wales' second current Commonwealth champion.
Evans' only defeat before Friday in his 11-fight professional career was a loss to Paul David in the semi-final of the 2010 super-middleweight Prizefighter tournament.
Jamaican-born McKenzie had lost his last two fights, both Commonwealth title challenges, to Tony Bellew who recently lost on points to another Welshman - WBO champion Nathan Cleverly.
The 31-year-old McKenzie, who now lives in Derby, previously lifted the Commonwealth title when he beat Peter Haymer in September 2006 but lost in his first defence to Dean Francis.