Britain's wait for an All England champion continues after Chris and Gabby Adcock joined Rajiv Ouseph in exiting in the quarter-finals.
The Adcocks lost 21-14 18-21 21-19 in the mixed doubles to Indonesia's defending champions Tontowi Ahmad and Liliyana Natsir.
Japan's Sho Sasaki overcame Ouseph 21-14 21-11 in the men's singles.
Spurred on by a partisan crowd at the Barclaycard Arena in Birmingham, the Adcocks made an aggressive start, but their Indonesian opponents were more than equal to the challenge.
England's Commonwealth gold medal-winning mixed-doubles duo recomposed themselves in the second game.
That momentum continued in the decider, but the three-time winners rallied to progress.
"We're devastated," said Gabby Adcock.
"There were times in the third game we really though we had them, but we couldn't quite get there."
Husband Chris added: "I'm sure in a few days, months, perhaps in years we can look back and take positives from this, but right now it really hurts."
Ahmad and Natsir are unbeaten at the event since 2011, having claimed the title in 2012, 2013 and 2014.
Ouseph, 28 produced the shock of the opening round by defeating third seed Son Wan-Ho of South Korea and followed that with an impressive comeback defeat of India's Prannoy Kumar.
But the London Olympian looked tired as his Egyptian rival dominated.
"I didn't train much for a couple of weeks because of injury ahead of this event and I felt that today," he told BBC Sport.
"I'm disappointed with today, but reaching my first All England quarter-final is a real positive."
Five-time men's singles champion Lin Dan of China eased through to the semi-finals with a 21-18 21-19 victory over Japan's Kento Momota and will face countryman Chen Long - the top seed - in Saturday's semi-final.
In the women's singles Tai Tzu Ying of Chinese Taipei defeated second seed Wang Shixian of China and joins China's Sun Yu in the final four.
Indian Olympic bronze medallist Saina Nehwal and Spain's Carolina Marin make up the other half of the draw.