The NFL will return to London in 2021, with two games played at the Tottenham Hotspur Stadium in October.
The Atlanta Falcons will host the New York Jets on Sunday, 10 October (14:30 BST) before Jacksonville Jaguars face Miami Dolphins the following Sunday.
London has hosted 28 games since 2007, but all of 2020's games were played in the United States due to the pandemic.
Fans will be able to see the first two picks in this year's draft in Jaguars' Trevor Lawrence and Jets' Zach Wilson.
"We expect these games to be a celebration of our sport," said Christopher Halpin, NFL executive vice-president - chief strategy & growth officer.
The Jaguars will be playing their eighth home game in London, while the Dolphins will play in the UK for the fifth time, with the Falcons and Jets both appearing in their second London game.
Bucs begin defence at home to Cowboys
Tom Brady and his Super Bowl-winning Tampa Bay Buccaneers will begin the defence of their title against the Dallas Cowboys on 9 September at Raymond James Stadium.
The Bucs beat the Kansas City Chiefs 31-9 in February to win their second Super Bowl title, and give Brady a record seventh success.
Cowboys quarterback Dak Prescott should return from a long-term ankle injury and play for the first time since signing a new four-year, $160m (£115m) deal in March.
The full schedule for the 2021 regular season is set to be released on Wednesday at 20:00 Eastern US time (01:00 BST on Thursday).
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