Patrick Mahomes and the Kansas City Chiefs bounced back from their loss to the Las Vegas Raiders by beating the Buffalo Bills 26-17 on Monday.
The Chiefs' loss to the Raiders last week ended a 13-match winning streak for the 2020 Super Bowl winners.
They responded by beating the Raiders with Mahomes throwing for two touchdowns and passing for 225 yards.
The 25-year-old connected with Travis Kelce for both touchdowns while Clyde Edwards-Helaire rushed for 161 yards.
Rookie running back Edwards-Helaire carried the ball 26 times to record his second 100-yard-plus game in his debut season.
"When you have days like this, things just seem to part like the Red Sea," said Edwards-Helaire.
The Bills had taken an early lead through Tyler Bass' 48-yard field goal and were 10-7 in front when Stefon Diggs touched down.
The Chiefs responded with 16 unanswered points and the Bills could not fight back, despite quarterback Josh Allen's eight-yard touchdown pass to Cole Beasley in the final quarter.
It was a second straight loss for the Bills who are now 4-2 for the season. The Chiefs remain top of the AFC West and are 5-1.