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Free Radicals

Melvyn Bragg and guests discuss the reactive atoms and molecules, with single unpaired electrons, linked to the process of ageing as well as normal cell functioning

Melvyn Bragg and guests discuss the properties of atoms or molecules with a single unpaired electron, which tend to be more reactive, keen to seize an electron to make it a pair. In the atmosphere, they are linked to reactions such as rusting. Free radicals came to prominence in the 1950s with the discovery that radiation poisoning operates through free radicals, as it splits water molecules and produces a very reactive hydroxyl radical which damages DNA and other molecules in the cell. There is also an argument that free radicals are a byproduct of normal respiration and over time they cause an accumulation of damage that is effectively the process of ageing. For all their negative associations, free radicals play an important role in signalling and are also linked with driving cell division, both cancer and normal cell division, even if they tend to become damaging when there are too many of them.

With

Nick Lane
Professor of Evolutionary Biochemistry at University College London

Anna Croft
Associate Professor at the Department of Chemical and Environmental Engineering at the University of Nottingham

And

Mike Murphy
Professor of Mitochondrial Redox Biology at Cambridge University

Producer: Simon Tillotson

Available now

42 minutes

Last on

Thu 1 Nov 2018 21:30

LINKS AND FURTHER READING

Nick Lane at University College London

Anna Croft at the University of Nottingham

Mike Murphy at the University of Cambridge

Moses Gomberg and the Discovery of Organic Free Radicals - American Chemical Society

Redox Biology Virtual Seminar Series - Society for Redox Biology and Medicine

Radical (chemistry) – Wikipedia

Antioxidant – Wikipedia

 

READING LIST:

Don Canfield, Oxygen: A Four Billion Year History (Princeton University Press, 2015)

Michael J. Davies and Roger T. Dean, Radical-Mediated Protein Oxidation: From Chemistry to Medicine (Oxford University Press, 1998)

Jacques Fossey, Daniel Lefort and Janine Sorba, Free Radicals in Organic Chemistry (John Wiley & Sons, 1995)

B. Giese, Radicals in Organic Synthesis: Formation of Carbon-Carbon Bonds (Pergamon, 1986)

Barry Halliwell and John Gutteridge, Free Radicals in Biology and Medicine (Oxford University Press, 2015)

Nick Lane, Oxygen: The Molecule that Made the World (Oxford University Press, 2002)

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