A late hat-trick from Robin van Persie helped Manchester United come from behind to beat Southampton 3-2.
Rickie Lambert headed the Saints in front in the first half, before RVP equalised at St Mary's.
After the break, Southampton's Morgan Schneiderlin helped put the hosts into a surprise lead.
Van Persie then missed a penalty but made up for it by scoring two goals in three minutes to seal the win.
Elsewhere, RVP's former club Arsenal beat Liverpool 2-0 at Anfield thanks to goals from Lukas Podolski and Santi Cazorla.
Newcastle drew with Aston Villa 1-1. Ciaran Clark scored for Villa, before Hatem Ben Arfa equalised for the Magpies.