Fifty staff at Wrexham's Glyndwr University have accepted voluntary redundancy as part of a shake-up of the organisation.
A further 10 jobs could go by compulsory redundancy although bosses say they are hopeful alternative employment could be found.
In July, staff took strike action over the jobs cuts after a ballot.
But the university said the changes were needed as the higher education sector "faces many challenges".
It first announced the shake-up in February prompting a backlash from staff and unions and protests.
A university spokesperson said: "At the outset, the university's board of governors and vice chancellor gave a commitment to explore all viable options for minimising or avoiding compulsory redundancies where possible.
"The university is satisfied that it has honoured that commitment and this is evidenced by the fact that the number of proposed compulsory redundancies has now been reduced to 10.
"Efforts to reduce further that number through alternative employment and voluntary severance continue in respect of those 10 roles."