A 25-year-old man has died following a three-vehicle collision on the A9 at Dunblane.
Police said the Honda Civic driver's 26-year-old female passenger was seriously injured in the crash, which happened at about 18:25 on Thursday.
The 41-year-old driver of a Mercedes Sprint van was also injured and remains in hospital.
The collision, north of the Keir roundabout, also involved a Volvo articulated lorry.
The A9 was closed in both directions and reopened at about midnight.
Sgt Michael Montague, of Forth Valley road policing unit, said: "A man has died in this collision and a passenger and one other driver seriously injured."
He appealed for anyone with information to contact police.