A man and a woman required hospital treatment after a crash which closed the A76 near Auldgirth.
The accident - involving two cars and a motorbike - happened a few miles north of Dumfries at about 12:25 on Thursday.
A 60-year-old German biker and a 54-year-old woman from Thornhill, who was driving one of the cars, were taken to Dumfries Infirmary.
An 83-year-old man from Thornhill, who was driving the second car, was unhurt in the crash.
The road was shut for several hours to allow accident investigations to take place.
It has since reopened.