Professor Sir John Arbuthnott is to receive the St Mungo Priz,e which honours the outstanding work of a son or daughter of Glasgow.
The renowned academic in the field of microbiology has served as principal of Strathclyde University and chairman of NHS Greater Glasgow and Clyde.
He will be presented with the award early next year.
The Glaswegian said he was "proud" to be honoured by the city he feels "most strongly about".
Sir John will be presented with the St Mungo Prize by Glasgow's Lord Provost Bob Winter next year.
As well as holding academic and health board positions, he has chaired the Scottish government's Commission on Boundary Differences and Voting Systems.
He also published the recent Clyde Valley Review, which recommended that councils collaborate to provide certain services.
Provost Winter said: "Sir John has provided continued support and advice to the city on a number of challenging issues over the last couple of years, including on public sector reform and health and wellbeing.
"The prize does not distinguish between status or wealth, but only on the good deeds done by an individual which have benefited our city and its citizens.
"Sir John, by his deeds and words, has devoted his life to the betterment of our great city and its people."
Sir John said he was "absolutely delighted and honoured" to receive the award.
He said: "Although I have worked in many places around the world, Glasgow, I regard, as my own city.
"It is where I was born and raised and the city I feel most strongly about and the one I am proud to have worked hardest for."