Two men aged 74 and 62 and a woman aged 64, have been charged with drugs-trafficking offences.
It follows the seizure of cannabis in south Belfast and Enniskillen on Monday.
The two men were arrested after cannabis worth an estimated £150,000 was found at a house at Donegall Road, south Belfast.
The woman was detained after drugs worth £100,000 were found at a house in Enniskillen in a follow-up search.
All three are expected to appear at Belfast Magistrates Court on Wednesday.