A 69-year-old man from Harrogate has died after his van was involved in a collision with a car on the A59 at Flaxby.
Police said the crash involving the Renault Kangoo van and a Volvo Estate happened at 1340 GMT on Friday.
The man suffered serious injuries and later died at Harrogate District Hospital. The car driver sustained minor injuries.
A North Yorkshire Police spokesman appealed for witnesses to contact them.