A woman and an 11-year-old boy have been seriously injured in a crash that closed the A27 in West Sussex.
A white Vauxhall Vivaro and red Peugeot 308 crashed in Shoreham at the crossroads with Coombes Road shortly before 05:30 GMT.
The Peugeot driver, a 50-year-old woman, and her passenger, the 11-year-old boy, have been taken to hospital in Brighton with serious injuries.
The 39-year-old male Vauxhall driver suffered minor injuries, police said.
The road was closed in both directions initially but has now fully reopened.
Police are appealing for witnesses.