Plans to double the size of a hazardous waste landfill site, for use until 2026, have been approved.
The Communities Secretary Eric Pickles has given permission for the site near King's Cliffe, Northamptonshire, following an inquiry by the National Infrastructure Planning Directorate.
The site already has permission to take delivery of low level radioactive material.
Mr Pickles said the development was of national significance.
He said the site is needed because of the demand for landfill capacity.
Campaigners against the scheme, King's Cliffe Waste Watchers, said they were disappointed but not surprised by the decision.
A spokesman for the group said the fight is now over.
Dr Gene Wilson, technical director of Augean Group who run the site, said: "Naturally we are very pleased that the application has been granted consent and determined that the company's proposal has been based on sound scientific, technical and policy grounds.
"The development consent order will enable us to continue to provide a nationally important facility for the safe, secure and well-regulated treatment and disposal of wastes that require specialist handling."