Manchester Airport train station was evacuated and a man detained after a suspicious bag was found while officers were investigating reports of a man behaving "erratically".
Greater Manchester Police said a cordon was put in place and bomb disposal officers carried out a controlled explosion.
Trains, trams and buses were suspended for a number of hours and the station reopened at 11:20 BST.
The detained man was taken to hospital.
Police confirmed the bag did not contain a viable device and there was "no evidence" to suggest the incident was terrorism related.
Ch Insp Andy Sutcliffe said: "Public safety is our top priority so a controlled explosion of a bag was carried out as a precaution before an inspection of the contents confirmed that there was no viable device or components inside."
Passengers were asked to follow directions from police officers as they were evacuated from the station and there were long queues for taxis.