Esther McVey has been selected as the Conservative candidate in Tatton after former Chancellor George Osborne said he would not to stand for re-election.
Former minister and Wirral West MP Ms McVey was chosen to contest the Cheshire constituency at a Conservative Party selection meeting on Wednesday.
Mr Osborne said he was leaving Parliament "for now" as he becomes the Evening Standard editor.
Ms McVey lost her seat as MP for Wirral West to Labour in the 2015 elections.
Mr Osborne congratulated Ms McVey on Twitter, saying: "A real star. I couldn't have a better successor. A one-woman Northern Powerhouse."
He had held the seat with a majority of more than 18,000.