Patrols will be stepped up and an alcohol exclusion zone will be installed ahead of Manchester's derby.
Manchester United will be travelling to Eastlands to take on City in the first derby match of the season later.
As well as police in the city centre and around the ground, Greater Manchester Police officers will be visiting pubs where the match is being shown live on television.
"We will take firm action if it is needed," Supt Jim Liggett said.
Anyone caught with alcohol on the streets within the exclusion zone, stretching from the city centre to the stadium, will have it confiscated.
In addition, anyone arriving at the stadium after drinking too much will be refused entry.
Sgt Liggett added: "The derby match always creates a good atmosphere and we want fans to enjoy what it is a great occasion in the football calendar.
"The overwhelming majority who attend football matches are there to support their teams but when a minority of people misbehave or come to games with the sole intention of causing trouble, it spoils it for everyone.
"This is a high-profile fixture and we have been working to ensure the game passes off peacefully."