The Yorkshire Air Ambulance (YAA) is to leave Leeds-Bradford International Airport for a new base in West Yorkshire.
A vacant site within the Nostell Priory estate, near Wakefield, has been granted planning permission by Wakefield Council.
It will have a hangar and aircrew accommodation for one helicopter.
The charity said the aircraft would operate in daylight hours only and should be operational by summer 2013.
The charity's two helicopters provide a "rapid response helicopter emergency medical service" for a population of approximately five million people.
The second air ambulance would continue to operate from RAF Topcliffe in North Yorkshire said the YAA.