Flood warnings have been issued for four rivers in Devon.
The warnings for the rivers Axe, Culm, Yarty and Otter mean that flooding of homes and businesses is likely.
The Met Office is predicting prolonged and heavy rain on Wednesday night.
Heavy rain in Devon on Tuesday night caused flooding at Otterton Mill near Budleigh Salterton and a woman was rescued when her car got stuck in flood water in Colyton.
A number of roads in Plymouth were closed on Wednesday morning due to flood waters.
Flooding also affected roads around South Brent and Holsworthy.
Ben Johnstone of the Environment Agency, which issued the flood warnings, said: "We are monitoring the situation closely.
"Our teams are on the ground clearing debris from rivers and grates, checking flood defences and assisting emergency services."
The warnings came after heavy rain caused severe disruption in neighbouring Cornwall where 100 homes were evacuated and main roads closed.