Derby County and Nottingham Forest supporters have been warned not to cause trouble as their teams meet at Pride Park.
Derbyshire Police has sent warning letters to known troublemakers telling them to stay away from the fixture.
Any supporter behaving in a disorderly way could receive a ban preventing them from attending future games at Pride Park or the City Ground.
The Championship match kicks off at 1300 GMT on Saturday.
Supt Gary Parkin, of Derbyshire Police, said: "We know this is the big one as far as both sets of fans are concerned and that it is the fixture that stands out in the calendar.
"It looks like it will be a full house and with the very recent game last month in Nottingham and the history between both clubs, the atmosphere will no doubt be super charged but that isn't an excuse for violent or aggressive behaviour.
"Our aim is to police the match, the city and surrounding areas in a fair way that ensures people can enjoy the day in a safe environment without any fear."
Thousands of Nottingham Forest fans will be attending the game and they are being reminded that there will be no alcohol on sale in the away concourses at half-time.