Richard Dawkins and Rowan Williams are to discuss the role of religion at a Cambridge Union debate.
Prominent atheist Prof Dawkins and the former Archbishop of Canterbury will discuss whether "religion has no place in the 21st Century" on Thursday.
They were involved in a public discussion at Oxford University last year.
Ben Kentish, president of the union, said it should be a highlight of the debating society's 200-year history.
"Our speakers are the most renowned commentators on this subject," he said.
In Cambridge, about 1,000 students will be in the audience.
"The prospect of seeing Professor Dawkins and the former Archbishop of Canterbury debate the subject is particularly exciting for our members," Mr Kentish said.
"It has all the makings of an excellent debate."
Professor Tariq Ramadan, Andrew Copson, the chief executive of the British Humanist Association, and Douglas Murray, founder of the Centre for Social Cohesion, will also take part.
The debate will be filmed and made available soon after on the union's website.
Previous speakers at the debating society include Sir Winston Churchill, Desmond Tutu and the Dalai Lama.