Designs from around the world have been submitted for the transformation of the Bristol Royal Infirmary (BRI).
The hospital trust is now asking the public for their opinions on six different designs.
The BRI Queen's Building on Upper Maudlin Street was once voted one of the ugliest in Bristol.
The proposals - which range from the use of glass panes to coloured panels - are part of a £80m redevelopment programme.
One of the designs is by a Bristol based artist, while the others have been submitted from London, France, Madrid, Stockholm and New York.
'Positive first impression'
University Hospitals Bristol NHS Foundation Trust (UH Bristol) decided to overhaul the front of the BRI building after discovering structural work was necessary to make it safe in the long-term.
Members of the public will have the opportunity to view the designs on Thursday at UH Bristol's Education and Research Centre, Upper Maudlin Street, from 10am until 7pm.
Robert Woolley, chief executive of UH Bristol, said: "I am really excited to have got international designers of this calibre giving us their ideas for changing the look of the BRI.
"We have long recognised that the appearance of BRI is not one that reflects the quality of care we give.
"The redevelopment project presents the opportunity to create a more positive first impression whether people are coming to the hospital or travelling through Bristol."
Following the public consultation a final shortlist of no more than three designs will be drawn up before a final decision is made by the Trust's board in July.
The refurbishment forms part of a wider programme, due to be completed in 2014, which will incorporate a new ward block, helipad and welcome centre.