Two people have died in a crash on the A421 Bedford bypass.
The collision, involving four cars and two lorries, happened on the eastbound carriageway near the A6 junction at about 14:10 GMT on Tuesday.
One person was pronounced dead at the scene and another died later at Bedford Hospital. Four other motorists were taken to hospital but are not in a critical condition.
A man has been arrested on suspicion of causing death by dangerous driving.
Both east and westbound carriageways were closed for most of the night between the Marsh Leys roundabout and the junction with the A600 but are now open.
Bedfordshire Police are appealing for witnesses including drivers with dashboard cameras.