The government spends more money on transport projects for Londoners than on those for the rest of the country combined, a think tank says.
The Institute for Public Policy Research North says £2,700 is spent per person in London compared with £5 per head in the north-east of England.
In a report out this week IPPR North says there is a "sharp disparity".
The government says its investment strategy is to maximise economic benefits for the country as a whole.
Ed Cox, Director of IPPR North, said: "Skewed spending benefiting London and the south-east is nothing new but these new figures are truly shocking and will strike most people as deeply unfair."
The BBC's Transport Correspondent Richard Lister says the report claims the infrastructure strategy is "entrenching the North-South divide".
IPPR North says almost half of the 20 biggest taxpayer-funded transport projects benefit only London and the south-east.
The Department for Transport said London is a global capital which supports a large number of commuters and it points out the government had recently approved additional investment of £1.4bn in transport schemes outside London.
But analysis by IPPR North shows almost half of major transport projects involving public funding benefit only London and the south-east, accounting for 84% of planned spending.
IPPR North says the "cost benefit analysis" equation currently used to decide where investment is targeted is wrong and that lack of spending constrains growth in the north of England.
Mr Cox conceded that much of the spending in London was due to the Olympics but he added: "If the government continue to use a system that reinforces the dominance of London and the south-east we'll all be worse-off in the long-run as the south becomes more congested while the north continues to fall behind in terms of growth."
IPPR North has called for a review of all future infrastructure projects ahead of the 2014 Spending Review.