The Witcher 3: Wild Hunt was the big winner at the Golden Joysticks picking up five awards.
The action, role-playing game won ultimate game of the year, best storytelling, best visual design and best gaming moment.
CD Projekt RED, the studio behind the game, also picked up studio of the year.
Now in its 33rd year, the Golden Joysticks are the only annual awards voted for by gamers.
Grand Theft Auto was the other big winner, picking up four awards.
It won innovation of the year for the introduction of its first-person mode in GTA 5.
It also walked away with best multi-player, best PC game and the PlayFire most played award.
Best original game and best PlayStation game went to Bloodborne, while the independently developed adventure platform Ori and the Blind Forest won best audio and best Xbox game.
This year's lifetime achievement award went to Satoru Iwata, the former Nintendo CEO, who died in July aged 55.
Iwata started as a programmer in a Nintendo subsidiary in the 1980s and became Nintendo president in 2002.
His aim was to make gaming less complex and open to everyone.
As well as helping to create many of Nintendo's most famous games, like Super Mario, The Legend of Zelda and Pokemon, he was also responsible for the DS and Wii.
Others winners included Kerbal Space Program for best indie game. Steam was once again named best gaming platform.
In perhaps the least surprising result of the night PewDiePie's 40 million subscribers made sure he picked up the gaming personality award for the second year running.
The full list of winners are...
Best original game: Bloodborne
Best storytelling: The Witcher 3: Wild Hunt
Best visual design: The Witcher 3: Wild Hunt
Best audio: Ori and the Blind Forest
Best multi-player: GTA Online
Best indie game: Kerbal Space Program
Best family game: Splatoon
Best mobile game: Fallout Shelter
Innovation of the year: First-person mode in GTA 5
Best gaming moment: Bloody Baron quest in The Witcher 3: Wild Hunt
Gaming personality: PewDiePie
eSports icon: Counter-Strike GO - Anders Blume
Studio of the year: CD Projekt RED
Best gaming platform: Steam
Best gaming performance: Ashly Burch as Chloe in Life is Strange
Best PlayStation game: Bloodborne
Best Nintendo game: Splatoon
Best PC game: GTA 5
Best Xbox game: Ori and the Blind Forest
Most wanted game: Fallout 4
Ultimate game of the year: Witcher 3: Wild Hunt
Lifetime achievement: Satoru Iwata
Playfire most played: GTA 5
Critics' choice: Metal Gear Solid V: The Phantom Pain
Breakthrough award: Her Story