The follow-up to Channel 4's Educating Yorkshire will be set in Walthamstow in north-east London.
The popular series, previously focusing on Passmores Academy in Essex and Thornhill Community Academy in Yorkshire, will be filmed at Frederick Bremer School.
The last series was Channel 4's highest-rating show of the year peaking with 4.8 million viewers.
It also won a Royal Television Society Award earlier this year.
The Frederick Bremer School, which opened in 2008, has seen big improvements in teaching and student progress under the lead of head teacher Jenny Smith and her staff.
Channel 4 producers describe their chosen school as "based in the heart of the community" and say it embraces "diversity and inclusivity".
Head teacher Jenny Smith said: "I am confident that Bremer will represent how committed community schools such as ours are to ensuring that every pupil is given every opportunity to succeed."
Channel 4's head of documentaries Nick Mirsky said that the series "shines a light on the tireless work which is carried out, unseen, day in, day out, by our public services with warmth and humour".
He added: "Frederick Bremer is a school which - although in a very different part of the country - shares with Thornhill Community Academy and Passmores a population of passionate and committed teachers and charismatic students."
As one of Channel 4's biggest hits of 2013, Educating Yorkshire featured English teacher Matthew Burton helping pupil Musharaf Asghar overcome his stammer using a technique from the King's Speech.
Critics described it as the most moving TV of the year.
The series inspired more than half a million tweets and its concluding episode was named the TV moment of the year by the Radio Times.
The new 10-part series doesn't have a title yet but will be the longest, up from seven episodes for Educating Essex, and eight (and a Christmas special) for Educating Yorkshire.
The series is set to be screened on Channel 4 later this year.
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