A third lockdown came into force on 6 January
A281 West Sussex both ways severe disruption, between Rushams Road and B2237 Bishopric Link Road.
A281 West Sussex - A281 Albion Way in Horsham blocked in both directions between the Rushams Road junction and the B2237 Bishopric Link Road junction, because of a fire at a building.
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The UK has begun the mass roll-out of a Covid-19 vaccination programme.
Ambulance officials in the South East are urging people to only call 999 in an emergency amid strong pressure on their service.
South East Coast Ambulance Service, which covers Kent, Sussex, Surrey and parts of Hampshire, said it was facing "very high demand".
It comes as the number of new daily confirmed cases of coronavirus topped 60,000 in the UK for the first time since the pandemic began.