The number of recorded serious knife offences - threats and attacks but not possession of blades - rose 25% in Leicestershire from September 2018 to 2019 compared to the previous 12 months
It puts the county sixth nationally behind Greater London, West Midlands, West Yorkshire, Merseyside and Bedfordshire, according to new figures released by the Office for National Statistics (ONS).
No figure was listed for Greater Manchester.
Derbyshire, which has a relatively low knife crime rate, saw an increase of 24% in the year to September.
Nottinghamshire saw the number of recorded serious knife offences dropping by 8%, making its knife crime rate lower than Leicestershire's.
Nottinghamshire bucked the national trend with England and Wales overall seeing a 7% increase.
The total number of serious knife offences in each county in the year to September were: Derbyshire 718, Leiecstershire 1,000, and Nottinghamshire 810.