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London Fire Brigade (LFB) said about 500 people were forced to leave the east London airport after some passengers felt unwell.
London Ambulance service said it was dealing with patients on the site and the LFB said it had appliances it uses when dealing with chemical incidents.
A spokesman for the airport said the evacuation took place at about 16:00 BST after a fire alarm was set off.
Up to 500 people have been evacuated from London City Airport in east London after a number of passengers reported feeling unwell following reports of a chemical incident, London Fire Brigade (LFB) has said.
The brigade was called at 16:11 BST and its crews, Metropolitan Police and London Ambulance Service (LAS) crews are still on site.
LFB said it has sent three fire engines and specialist appliances used to deal with chemical incidents.
LAS said it is dealing with patients at the scene.
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London City Airport has been evacuated following a fire alert. Hundreds of passengers were ordered to leave the terminal building and no flights were able to take off or land.
Several incoming flights from destinations such as Frankfurt, Amsterdam, Belfast City and Paris were diverted to other airports.
A London City Airport spokeswoman said the cause of the alarm was being investigated. She could not confirm whether a fire had been discovered.
London Fire Brigade said it was called to the airport at 16.11 on Friday.
Three fire engines and 15 firefighters were sent to the scene to work alongside crews based at the airport.