The highest tier of coronavirus restrictions will be imposed on Greater Manchester from 00:01 BST on Friday 23 October, and in South Yorkshire from 00:01 on Saturday.
It means the areas will be moved from Tier 2 (high risk), to Tier 3 (very high risk), joining the Liverpool City Region and Lancashire.
Other parts of the UK have also introduced additional coronavirus restrictions.
How does England's new three-tier system work?
Every area of England now falls into one of three categories - medium (Tier 1), high (Tier 2) or very high (Tier 3), depending on the local rate of infection.
What are the rules in Tier 3?
Areas with the most rapidly rising transmission rates are placed in Tier 3.
You are not allowed to meet socially with anybody who is not part of your household, or support bubble, indoors.
You cannot meet in private or pub gardens, but can meet in parks, beaches, countryside or forests, as long as you are not in a group of more than six.
Pubs and bars must close unless they are serving substantial meals. Alcohol can only be served as part of a meal.
People are being advised not to travel into or out of Tier 3 areas, other than for work, education, youth services or because of caring responsibilities.
Casinos, bingo halls and betting shops, adult gaming centres and soft play areas have closed in all Tier 3 areas.
Extra measures can be introduced, following discussions between central and local government. In Lancashire, car boot sales are not allowed, while gyms in the Liverpool City Region were initially closed but have been told they will be able to reopen.
The latest restrictions will be imposed in Greater Manchester from 00:01 BST on Friday 23 October after the mayor, Andy Burnham, said the government had "walked away" from negotiations after refusing his request for £65m financial support.
Prime Minister Boris Johnson said "not to act now" would put the lives of Manchester's residents "at risk".
The restrictions in Greater Manchester will be reviewed by at least 11 November.
All four local authority areas of South Yorkshire - Barnsley, Doncaster, Rotherham and Sheffield - will also be moved into Tier 3 on Saturday, Sheffield Mayor Dan Jarvis has confirmed.
Gyms are to stay open there, but gym classes will not be allowed.
What are the rules for Tier 2?
You are not allowed to meet socially with people you do not live with indoors - this includes private homes, as well as pubs or restaurants.
People in support bubbles can go on meeting as before and informal childcare may also be provided.
You can still meet friends and family outdoors, but only in a group of up to six people.
What are the rules for Tier 1?
Areas in Tier 1 are subject to the basic national rules previously in force.
You may not meet in a group of more than six people, indoors or outdoors, unless you're in a larger household or a support bubble.
Pubs, bars and restaurants in a Tier 1 area must close by 22:00 BST.
What are the new rules in Wales?
From 18:00 on Friday 23 October until the start of Monday 9 November, Wales will go into a ''short, sharp'' circuit-break, a mini lockdown in which:
- People will be told to stay at home in most circumstances
- Secondary school pupils above year 8 will switch to online learning only
- People must not visit other households or meet people they do not live with
- Pubs, restaurants and non-essential shops will close
- Leisure businesses, community centres, libraries and recycling centres will also shut
- Places of worship will be closed for normal services, except for funerals and weddings
Adults living alone or single parents will be able to join with one other household for support from anywhere in Wales.
What are Northern Ireland's new rules?
Northern Ireland has introduced four weeks of restrictions. Schools have closed for a two-week extended half-term break and will reopen on 2 November.
Other measures include:
- Pubs, bars and restaurants must close, except for takeaways and deliveries, which must stop by 23:00 BST
- Support bubbles will be limited to a maximum of 10 people from two households
- You are not allowed to stay overnight in someone else's home, unless they are part of your bubble
- Close-contact services such as hairdressers and beauticians must close, except for essential services
- No indoor or contact sport allowed unless at elite level; gyms stay open for individual exercise only
- No mass events of more than 15 people, apart from certain sporting events
- Wedding ceremonies limited to 25 people, with no receptions
- Funerals limited to 25 people, with no wakes allowed before or afterwards
What are the current restrictions in Scotland?
Scotland is planning to introduce a five-tier system of restrictions in early November.
In the meantime, restrictions in Scotland, which were due to run until 25 October, have been extended by another week.
This includes the tougher rules imposed on 3.4 million people in central Scotland.
The region affected covers 18 local council and five health board areas (Greater Glasgow & Clyde, Lanarkshire, Ayrshire & Arran, Lothian, Forth Valley).
In these areas, all licensed premises - with the exception of hotel bars for residents - have to close indoors and outdoors, though takeaways are permitted.
Cafes can stay open until 18:00 daily, as long as they don't serve alcohol.
People living in these areas have been told to avoid public transport, unless absolutely necessary, and not to leave their local areas if possible (people from outside are encouraged not to visit).
Other measures include the closing of snooker halls, bowling alleys, casinos and bingo halls, the suspension of non-professional contact sports and indoor group exercise for adults.
In the rest of Scotland, pubs and restaurants can only open inside between 06:00 and 18:00 daily, and they are not allowed to serve alcohol.
They are only allowed to serve food and non-alcoholic drinks, although they can serve alcohol outdoors until 22:00.
Hotel restaurants can serve food after 18:00, but only for residents and without alcohol.
Throughout the nation, face coverings are compulsory in indoor communal settings, such as staff canteens and corridors in workplaces.
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