The Revenant director Inarritu clinched the best director gong - an award he lost last year to Richard Linklater. "There is nobody more deserving of that trust than our director Alejandro G Inarritu," said his leading man Leonardo DiCaprio. "I've never had an experience like this in my entire life. The depths he went to are unfathomable."
It was a good night for the Amazon hacking drama Mr Robot - currently in its first season. The series picked up two awards, including one for Christian Slater. However the show's lead, Rami Malek, lost out to Mad Men's Jon Hamm
Good friends Amy Schumer and Jennifer Lawrence introduced their respective films Trainwreck and Joy. Lawrence went on win the best actress in a comedy film prize for her role as the inventor of the Miracle Mop in David O Russell's Joy. She told the filmmaker: " I want to be buried beside you."
Singer Sam Smith and songwriter Jimmy Napes collected the Golden Globe for best original song, for Writing's On The Wall from the recent James Bond film Spectre. Adele's Skyfall is the only other Bond theme to have won a Golden Globe.
Brie Larson's best actress win was the only award for Room, the adaptation of Emma Donoghue's best-selling book - in a closely fought race with Saoirse Ronan. The 21 Jump Street star is widely expected to be nominated for an Oscar on Thursday.
Host Ricky Gervais had an awkward reunion with presenter Mel Gibson, whom he previously mocked when he fronted the awards in 2012. "I love seeing Ricky every three years because it reminds me to get a colonoscopy," said a testy Gibson.
The Martian picked up two Golden Globes in the 'comedy' category - though even director Ridley Scott appeared to question whether it could really be classed as such, when he picked up the award for best comedy film. Nonetheless the film's star, Matt Damon, was hailed by Scott for "his special brand of humour and grace".
Singer Lady Gaga was an emotional winner of the 'best performance by an actress in a mini-series or motion picture made for television', for her turn in American Horror Story: Hotel. The star - who confessed on the red carpet to saying a prayer in the car en route - said: "I wanted to be an actress before I was a singer, but music worked out first. I'm truly speechless."
Presenters Mark Wahlberg and Will Ferrell donned some eye-popping 2016 spectacles to present the award for best screenplay to West Wing creator Aaron Sorkin for his work on Steve Jobs.
"I honestly, truthfully didn't expect this at all," said Winslet, as she picked up one of two awards for the eponymous biopic Steve Jobs. Winslet plays Jobs' dowdy assistant Joanna Hoffman in the film opposite Michael Fassbender. Fassbender lost out to DiCaprio in the battle for best dramatic actor.