US photographer Annie Leibovitz has won the prestigious Prince of Asturias award for humanities in Madrid.
One of the world's top portrait photographers, the jury hailed her as a "driving force" in photojournalism.
Her pictures, which include singer John Lennon naked and actress Demi Moore pregnant, "reflect an era of politics, literature, film, music and sport".
Leibovitz will be presented with the 50,000 euro (£40,000) prize, one of Spain's highest honours, in October.
Her shots have made the front pages of magazines such as Rolling Stone, where she started her career in 1970, and Vogue, for which she has worked for the last 15 years. She is also a contributing editor at Vanity Fair.
One of her best-known cover shots was for Vanity Fair in 1991, when she photographed a naked Moore, who was seven months pregnant.
She has captured a number of American presidents, including Richard Nixon as he quit the White House and George W Bush's government as it met shortly after the attacks of 11 September 2001.
The Prince of Asturias communication and humanities award is given to an individual or institution whose work promotes the "humanistic values that form part of mankind's universal heritage".
Last year it went to Japanese video game designer Shigeru Miyamoto. Other previous winners include The National Geographic Society and Google.
The humanities prize is one of eight given in different fields by the foundation each year.
Austrian film-maker Michael Haneke has already won the arts prize for his "relentless, personal exposure of reality".